Clinical efficacy and safety of doxazosin combined with desmopressin in treatment of nocturia in patients with benign prostatic hyperplasia
10.3760/cma.j.issn.1671-7368.2016.01.015
- VernacularTitle:多沙唑嗪联合去氨加压素治疗前列腺增生患者夜尿增多的疗效及安全性研究
- Author:
Jianlong WANG
;
Yaoguang ZHANG
;
Ming LIU
;
Ben WAN
;
Jianye WANG
- Publication Type:Journal Article
- Keywords:
Deamino arginine vasopressin;
Nocturia;
Prostatic hyperplasia
- From:
Chinese Journal of General Practitioners
2016;15(1):50-52
- CountryChina
- Language:Chinese
-
Abstract:
Thirty six patients aged 50-70 years with benign prostatic hyperplasia (BPH) received doxazosin and desmopressin treatment for 4 weeks.After treatment the International Prostate Symptom Scores (IPSS) and Quality of Life (QoL) scores of patients were significantly improved (17.4 ± 2.5 vs.11.8 ± 1.1 and 3.9 ±0.6 vs.1.8 ± 1.3,respectively;both P < 0.01).The nocturia frequency was decreased from 4.6±1.5 to 2.1±1.6 (P<0.01);nocturnal urine output from (564±73) to (348±45) ml (P<0.05);the hours of undisturbed sleep increased from (88.6 ± 17.5) min to (146.2 ± 12.8) min (P <0.05).There were no significant differences in serum levels of sodium,potassium and chlorine,and osmoticpressure before and after treatment.The results indicate that doxazosin combined with desmopressin is safe and effective for treatment of nocturia in patients with BPH.