Clinical efficacy and safety of doxazosin combined with desmopressin in treatment of nocturia in patients with benign prostatic hyperplasia

VernacularTitle:多沙唑嗪联合去氨加压素治疗前列腺增生患者夜尿增多的疗效及安全性研究
Author: Jianlong WANG ; Yaoguang ZHANG ; Ming LIU ; Ben WAN ; Jianye WANG
Publication Type:Journal Article
Keywords: Deamino arginine vasopressin; Nocturia; Prostatic hyperplasia
From: Chinese Journal of General Practitioners 2016;15(1):50-52
CountryChina
Language:Chinese
Abstract: Thirty six patients aged 50-70 years with benign prostatic hyperplasia (BPH) received doxazosin and desmopressin treatment for 4 weeks.After treatment the International Prostate Symptom Scores (IPSS) and Quality of Life (QoL) scores of patients were significantly improved (17.4 ± 2.5 vs.11.8 ± 1.1 and 3.9 ±0.6 vs.1.8 ± 1.3,respectively;both P ＜ 0.01).The nocturia frequency was decreased from 4.6±1.5 to 2.1±1.6 (P＜0.01);nocturnal urine output from (564±73) to (348±45) ml (P＜0.05);the hours of undisturbed sleep increased from (88.6 ± 17.5) min to (146.2 ± 12.8) min (P ＜0.05).There were no significant differences in serum levels of sodium,potassium and chlorine,and osmoticpressure before and after treatment.The results indicate that doxazosin combined with desmopressin is safe and effective for treatment of nocturia in patients with BPH.