Incidence of levodopa-induced dyskinesia in ederly patients with Parkinson's disease and related factors

VernacularTitle:60岁及以上帕金森病患者左旋多巴诱发运动障碍发生率及相关因素分析
Author: Shuhua LI ; Wen SU ; Xiangyu ZENG ; Haibo CHEN ; Xiaojie CAI
Publication Type:Journal Article
Keywords: Dyskinesia,drug-induced; Parkinson disease; Levodopa
From: Chinese Journal of General Practitioners 2016;15(1):53-55
CountryChina
Language:Chinese
Abstract: One hundred patients with Parkinson's disease (PD) aged 60 and above treated with levodopa were enrolled in this cross section study.The general conditions,medication,unified Parkinson's disease rating scale (UPDRS) scores and the incidence of levodopa-induced dyskinesia (LID) were documented.The incidence rate of LID in this group of PD patients was 37.0％ (37/100).The incidence was significantly higher in patients with levodopa treatment ≥ 4 years than that in patients with levodopa treatment ＜ 4 years (55％ vs.26％,x2 =8.770,P =0.003).The incidence rate ofpeak dosage dyskinesia in tremor-dominant PD patients was lower than that in rigidity-dominant PD patients(x2 =4.399,P =0.036).The incidence rate of LID was correlated with the duration of levodopa therapy.Amantadine may reduce the incidence of off dystonia.