Total parathyroidectomy with subcutaneous autotransplantation in the treatment of secondary hyperparathyroidism in patients with chronic renal failure
10.3760/cma.j.issn.1007-631X.2016.04.021
- VernacularTitle:甲状旁腺全切除加前臂皮下移植术治疗慢性肾衰继发性甲状旁腺功能亢进症
- Author:
Jin MA
;
Xiaoping GENG
;
Jiangming CHEN
;
Shengxue XIE
;
Liquan YU
;
Peikun LI
- Publication Type:Journal Article
- Keywords:
Kidney failure,chronic;
Hyperparathyroidism,secondary;
Parathyroidectomy;
Autotransplantation;
Quality of life
- From:
Chinese Journal of General Surgery
2016;31(4):333-337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical effect of total parathyroidectomy with subcutaneous autotransplantation (TPTX + AT) in the treatment of secondary hyperparathyroidism(SHPT) in patients with chronic renal failure.Methods One hundred and thirty-four patients undergoing TPTX + AT in our hospital from January 2013 to October 2014 were includud in this study.The preoperative,postoperative and follow-up intact parathyroid hormone (iPTH),serum calcium,serum phosphorus and calcium-phosphorus product were statistically analyzed.The Kidney Disease Quality of Life Short Form (KDQOL-SFTM) scale was used to evaluate quality of life before and one year after parathyroidectomy.Postoperative complications and recurrence were observed.Results Postoperative iPTH,serum calcium,serum phosphorus and calciumphosphorus product decreased significantly compared with that before surgery.The difference had statistical significance (all P ＜ 0.05).One patient died in perioperative period.Temporary injury of recurrent laryngeal nerve was found in eight patients.Early postoperative hypocalcemia was frequently seen in 124 patients (92.5％) and in 7 cases (5.2％) occured intractable hypocalcemia.The quality of life was significantly improved one year after parathyroidectomy.Recurrence developed in 5 patients after operation.Conclusions TPTX + AT is safe and effective in the treatment of SHPT in patients with chronic renal failure and can significantly improve the patient's quality of life.
