Long-term effects of L-T4 treatment on physical and intellectual development for congenital hypothyroidism
10.3760/cma.j.issn.1000-6699.2015.10.013
- VernacularTitle:左旋甲状腺素治疗新生儿先天性甲状腺功能减退体、智发育的远期疗效
- Author:
Peihua FANG
;
Ning LI
;
Jinyan CHAI
;
Jingyan YANG
;
Mei LYU
;
Guangyu HUANG
;
Chengyun YUAN
- Publication Type:Journal Article
- Keywords:
Hypothyroidism;
Long-term effects;
Neonatal screening;
Adolescence;
Adulthood
- From:
Chinese Journal of Endocrinology and Metabolism
2015;31(10):887-890
- CountryChina
- Language:Chinese
-
Abstract:
To explore the long-term effects of L-T4 treatment on physical and intellectual development in neonatal congenital hypothyroidism(CH) patients during adolescence and adulthood.14 out of 15 patients,aged 15-31 years old,including 9 males and 6 females,were diagnosed by neonatal screening for congenital hypothyroidism.(1) By treatment for 10 years until adolescence,return visit ages were 12.6-18.1 years old,the height of patients were normal in 14 cases,weight normal in 8 cases,and overweight in 6 cases.Only the first patient of neonatal screening for congenital hypothyroidism height 154 cm,weight of 43.5 kg,which were below the standard.Bone age by X-ray showed 9 normal,1 case of rapid development,4 cases with left wrist bone age retardation.IQ combined Raven's test(CRT) showed 3 cases excellent,7 cases normal,3 cases borderline,and 2 cases low.(2)Treatment for more than 20 years to adulthood,9 cases of return visits (8 cases were screened out) by 23-31 years of age,with 5 males and 4 females,height and bone age were all normal,normal weight,only 2 cases BMI slightly overweight.As to IQ,good were in 7 cases,mild retardation in 2 cases.7 patients received above average education;they were all employed except one.The employed patients were all capable for their jobs.In summary,screening out of 8 patients,1 case were of mild mental retardation (12.5％);while 7 patients(87.5％),both in physical and intellectual levels were as those of the normal population.
