Role of potassium channel in remifentanil-induced prolongation of monophasic action potential duration in myocardium of rabbits
10.3760/cma.j.issn.0254-1416.2016.02.007
- VernacularTitle:钾通道在瑞芬太尼延长家兔心肌单相动作电位时程中的作用
- Author:
Yanqiu LIU
;
Hong GAO
;
Li AN
;
Kaiqiang ZHANG
;
Juan LONG
;
Chao CHEN
- Publication Type:Journal Article
- Keywords:
Piperidines;
Potassium channels;
Action potentials;
Bradycardia
- From:
Chinese Journal of Anesthesiology
2016;36(2):151-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of potassium channel in remifentanil-induced prolongation of monophasic action potential duration (MAPD) in the myocardium of rabbits.Methods Eighteen adult rabbit hearts successfully perfused in a Langendorff apparatus were randomly divided into 3 groups (n =6 each) using a random number table:control group (group C),remifentanil group (group R),and K+ channel blocker tetraethylammonium group (group T).After 15 min stabilization with K-H solution,group C was continuously perfused with K-H solution for 60 min,and R and T groups were perfused with KH solution containing 12 ng/ml remifentanil and 10 ng/ml tetraethylammonium,respectively,for 60 min.At 15 min of stabilization,and 15,30 and 60 min of perfusion,heart rate,MAPD of all the three layers of the myocardium in the anterior wall of the left ventricular was recorded.MAPD at 50％ and 90％ repolarization (MAPD50,MAPD90) were calculated.Results Compared with group C,heart rate was significantly decreased,MAPD50 and MAPD90 were prolonged in R and T groups (P ＜0.05).Conclusion The mechanism by which remifentanil prolongs MAPD in the myocardium of rabbits is associated with blockade of the potassium channels.
