Effect of dexmedetomidine on postoperative cognitive function in elderly patients with fragile brain
10.3760/cma.j.issn.0254-1416.2016.02.004
- VernacularTitle:右美托咪定对老年脆弱脑功能患者术后认知功能的影响
- Author:
Lili TANG
;
Erwei GU
;
Lei ZHANG
;
Xunqin LIU
;
Yuanyuan CAO
;
Xinqi CHENG
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Delirium;
Cognition disorders;
Aged;
Fragile brain
- From:
Chinese Journal of Anesthesiology
2016;36(2):140-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of dexmedetomidine on the postoperative cognitive function in the elderly patients with fragile brain.Methods One hundred and twenty elderly patients with fragile brain,aged 65-85 yr,weighing 50-80 kg,of American Society of Anesthesiologists physical status Ⅱ or Ⅲ,with preoperative Mini-Mental State Examination score≥ 20,scheduled for elective gastroenteric surgical procedures,were randomly assigned to one of 2 groups (n =60 each) using a random number table:control group (group C) and dexmedetomidine group (group D).In group D,dexmedetomidine was intravenously infused in a loading dose of 0.4 μg/kg over 10 min before anesthesia induction,followed by an infusion of 0.4 μg · kg-1 · h 1until 30 min before the end of surgery.While the equal volume of 0.9％ nomal saline was given instead of dexmedetomidine in group C.Postoperative delirium was assessed within 3 days after operation using Confusion Assessment Method.Postoperative cognitive dysfunction was assessed at 7 days after operation using Mini-Mental State Examination.Results Compared with group C,the incidence of postoperative delirium was significantly decreased within 3 days after operation (P＜ 0.05),and no significant change was found in postoperative cognitive dysfunction at 7 days after operation in group D (P＞0.05).Conclusion Dexmedetomidine can decrease the occurrence of postoperative delirium in the elderly patients with fragile brain.
