Presumed Intraocular Natural Killer/T-cell Lymphoma Combined with Nasal Lymphoma.
10.3341/jkos.2011.52.7.871
- Author:
Hoon Seok JEONG
1
;
Sang Hui PARK
;
Jae Hoon LEE
;
Dae Yeong LEE
;
Dong Heun NAM
Author Information
1. Department of Ophthalmology, Gil Hospital, Gachon University of Medicine and Science, Incheon, Korea. eyedawns@gilhospital.com
- Publication Type:Case Report
- Keywords:
Diagnostic vitrectomy;
Intraocular natural killer/T-cell lymphoma
- MeSH:
Anterior Chamber;
Eye;
Follow-Up Studies;
Humans;
Intravitreal Injections;
Lymphocytes;
Lymphoma;
Male;
Methotrexate;
Middle Aged;
Neoplasm Metastasis;
Recurrence;
RNA;
Uveitis;
Vitrectomy
- From:Journal of the Korean Ophthalmological Society
2011;52(7):871-875
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report a case of presumed intraocular natural killer/T-cell lymphoma (NKTL). CASE SUMMARY: A 61-year-old male presented with visual disturbance of the left eye for duration of 3 years. He had been treated with systemic chemotherapy and radiotherapy for nasal NKTL 1 year prior. Inflammatory reaction in the anterior chamber and vitreous opacity were observed in the left eye. The patient was diagnosed with uveitis in the left eye at a local clinic 3 years prior to visiting us. Because the patient did not respond to anti-inflammatory therapy, we performed diagnostic and therapeutic vitrectomy. Intraoperatively, vitreous opacity was thin sheet like in appearance. The vitreous specimen contained few lymphoid cells and was positive for Epstein Barr virus-encoded RNA (EBER). Systemic workups showed no metastasis to other organs. The patient was treated with systemic methotrexate chemotherapy and intravitreal methotrexate injected 3 times (once per week). During the 12-month follow-up period after the last intravitreal injection, the recurrence of lymphoma and related uveitis was not observed.
