Renal IgG subclasses in hepatitis-related nephropathy patient with negative plasma hepatitis B antigen
10.3760/cma.j.issn.1008-6315.2016.01.013
- VernacularTitle:血乙肝病毒抗原阴性的乙肝病毒相关性肾炎患者肾组织IgG亚型特点
- Author:
Danna MA
;
Haijing LIU
;
Wanzhong ZOU
;
Danxia ZHENG
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Nephropathy;
IgG subclass
- From:
Clinical Medicine of China
2016;32(1):44-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the renal IgG subclasses in special patients whose renal HBsAg and HBcAg are positive, but plasma HBsAg, HBeAg, and HBcAg are negative.Methods Renal IgG subclasses were compared between 14 cases hepatitis-related nephropathy patients(diagnosed by renal biopsy pathology,whose blood hepatitis B antigens were negative) and 18 cases idiopathic membranous nephropathy patients.HBcAg and HBsAg were detected by indirect immunofluorescence assay, IgG, IgG1, 2, 3, 4 were stained by immunofluorescence.Results Renal IgG1-4 deposits were 100％ (14/14), 78.6％ (11/14), 78.6％ (11/14), 100％(14/14) separately in hepatitis B-related nephropathy group, and renal IgG1-4 deposits were 88.9％ (16/18), 5.6％ (1/18), 5.6％ (1/18), and 83.3％ (15/18) in idiopathic membranous nephropathy group.Renal IgG2 and IgG3 deposit more in hepatitis B-related nephropathy group than in idiopathic membranous nephropathy group (78.6％ vs 5.6％ ,78.6％ vs 5.6％;P =0.000) , but no significant difference in IgG1 and IgG4 deposit.Conclusion Renal IgG2 and IgG3 deposit more in hepatitis B-related nephropathy group than in idiopathic membranous nephropathy group, and may help some in diagnosis.
