Correlation between promoter methylation of hMLH1 and DAPK genes and drug resistance of lung cancer
10.3760/cma.j.issn.1006-9801.2016.03.017
- VernacularTitle:hMLH1、DAPK基因启动子区甲基化与肺癌耐药的相关性
- Author:
Peipei WANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
hMLH1;
DAPK;
DNA methylation;
Drug resistance,neoplasms
- From:
Cancer Research and Clinic
2016;28(3):207-209
- CountryChina
- Language:Chinese
-
Abstract:
Drug resistance is one of the major obstacles for chemotherapy and targeted therapy in lung cancer with complex mechanisms.The researches have demonstrated that epigenetic changes are closely related to drug resistance of tumor.DNA methylation is an important epigenetic modification.In this paper, the relationships between hMLH1 promoter aberrant methylation and platinum-resistance, and DAPK promoter aberrant methylation and EGFR-TKI resistance in lung cancer will be briefly reviewed.
