Efficacy of CO2 fractional laser combined with 5-aminolevulinic acid photodynamic therapy on refractory verruca plana
10.3760/cma.j.issn.1671-0290.2015.06.008
- VernacularTitle:二氧化碳点阵激光联合5-氨基酮戊酸光动力疗法治疗顽固性扁平疣的临床效果
- Author:
Xingcun ZHANG
;
Hongzhen YANG
;
Yunchuan YANG
;
Yongfang ZENG
;
Yuangang LU
- Publication Type:Journal Article
- Keywords:
Flat wart;
CO2 fractional laser;
5-aminolevulinic acid (ALA)-mediated photodynamic therapy
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2015;21(6):344-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the safety and efficacy of CO2 fractional laser combined with 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (ALA-PDT) for the treatment of refractory flat wart.Methods The 80 patients with facial flat wart were randomly divided into observation group (40 cases) and control group (40 cases).The observation group was treated with CO2 fractional laser combined with 5-ALA-PDT,and the control group was treated with 5-ALA-PDT only.Those with residual lesions after the first treatment were treated with the second or third times.The interval duration between treatments was 2 weeks.The efficacy and the adverse reaction were evaluated after the 2-week,4-week and 6-month after the last treatment.Results Compared with prior treatment,the facial lesions achieved complete response and improvement.The total effective rate of the observation group were 90.0％ (36/40) and 72.5％ (29/40) for the control group,the difference was statistically significant (P＜0.05).There were 2 cases of pigmentation occurred in observation group and 3 cases in control group.The complications including infection and hypertrophic scar were seldom occurred in the two groups.Conclusions The safety and efficacy of CO2 fractional laser combined with ALA-PDT are better than that with ALA-PDT only in the treatment of refractory flat wart.
