Expression of phosphorylated mammalian target of rapamycin (p-mTOR) and phosphorylated eukaryotic translation initiation factor 4E binding protein 1 in pathologic scar
10.3760/cma.j.issn.1671-0290.2015.06.014
- VernacularTitle:磷酸化哺乳动物雷帕霉素靶蛋白和磷酸化真核细胞翻译启示因子4E结合蛋白1在病理性瘢痕中的表达
- Author:
Gongbao ZHANG
;
Tao DAI
;
Depin YUAN
;
Shuying CUI
;
Chengshu ZHANG
;
Yanling LI
;
Ding CHENG
- Publication Type:Journal Article
- Keywords:
Phosphorylated mammalian target of rapamycin;
Phosphorylated eukaryotic translation initiation factor 4E binding protein 1;
Pathologic scar;
Keloid;
Hypertrophic scar
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2015;21(6):365-368
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of phosphorylated mammalian target of rapamycin (p-mTOR) and phosphorylated eukaryotic translation initiation factor 4E binding protein 1 (p-4EBP1) in pathologic scar,and comprehend its role and significance in the pathologic scar formation.Methods SP immunohistochemical method was used to detect the expression of p-mTOR and p-4EBP1 in 20 cases of keloid,20 cases of hypertrophic scar,20 cases of non-pathologic scar and 20 cases of normal skin tissue.The positive rates of expression in different tissues were analyzed,and the relationship in pathological scar was explored.Results The positive rates of p-mTOR and p-4EBP1 in keloidand hypertrophic scar were 75.0％ (15/20),60.0％ (12/20) and 60.0％ (12/20),50.0％ (10/20),nom-pathologic scars were 20％ (4/20),10％ (2/20);normal skin tissue were 10％ (2/20),5％ (1/20),which were higher respectively compared with the two control groups (P＜ 0.05);there was a highly positive correlation between p-mTOR and p-4EBP1 expression in pathologic scar (r=0.323,P＜0.05).Conclusions p-mTOR and p-4EBP1 might be involved and cooperated in promoting the progress of pathologic scars.
