Glycosylation and biomarkers in primary liver cancer
10.3760/cma.j.issn.1009-9158.2016.02.001
- VernacularTitle:糖基化与原发性肝癌标志物
- Author:
Meng FANG
;
Chunfang GAO
- Publication Type:Journal Article
- Keywords:
Liver Neoplasms;
Glycosylation;
Glycosyltransferases;
Tumor Markers,Biological;
Early Diagnosis
- From:
Chinese Journal of Laboratory Medicine
2016;39(2):73-75
- CountryChina
- Language:Chinese
-
Abstract:
Primary liver cancer (PLC) is the second leading cause of cancer death in China,and is one of the most serious threats to people's health.Early diagnosis and treatment can significantly improve the prognosis of PLC.Abnormal glycosylation is reported to be closely related to the genesis and development of malignant tumors.With the advent of modern proteomic and glycomic methodologies,several alterations in fucosylation,sialylation,and glycan branching have been observed in serum of patients with PLC.Altered glycosylation profiles,glycosyltransferases and glycosylated proteins could be screened and used as potential serum markers for early diagnosis,progression monitoring and prognosis evaluation of PLC.
