Retrospect and prospect of IP-10 in the pathogenesis of autoimmune diseases
10.3760/cma.j.issn.1009-9158.2015.12.004
- VernacularTitle:IP-10在自身免疫病发病中的作用及应用前景
- Author:
Qing LIN
;
Yanfang SONG
- Publication Type:Journal Article
- Keywords:
Autoimmune diseases;
Chemokine CXCL10;
Biological markers
- From:
Chinese Journal of Laboratory Medicine
2015;38(12):805-808
- CountryChina
- Language:Chinese
-
Abstract:
Interferon-γ-inducible protein 10 (IP-10),also known as chemokine (C-X-C motif) ligand 10(CXCL10),belongs to the CXC subfamily.IP-10 exerts its function by binding to chemokine (C-X-C motif) receptor 3 or Toll-like receptor 4.IP-10 plays an important role in the occurrence and development of autoimmune diseases.The expression of IP-10 in blood and body fluid is closely associated with the activity of autoimmune disease.IP-10 is expected to become a potential new marker and possess a significant application value in early screening,condition monitoring and therapeutic evaluation of autoimmune diseases.
