The current status and outlook of NF-κB and myocardial ischemia/reperfusion injury
10.3760/cma.j.issn.1001-4497.2016.01.020
- VernacularTitle:NF-κB与心肌缺血再灌注损伤的研究现状及展望
- Author:
Xinyu LIU
;
Jianmin GU
;
Song XUE
- Publication Type:Journal Article
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2016;32(1):55-58
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial ischemia/reperfusion(MI/R) injury refers to restoring blood perfusion after myocardial ischemia for a relatively long time, but the tissue appears more obvious and severe myocardial damage and dysfunction than before reperfusion, this phenomenon mainly relates to inflammation, oxidative stress, cell apoptosis, cell autophagy and so on.NF-κB is a nuclear transcription factor involved in regulating a variety of pathophysiological processes, which also plays an important role in all aspects of MI/R injury.The in-depth study of NF-κB in MI/R injury and clinical application of related research will provide new ideas and methods for treating MI/R injury.
