The plasma expressions of monocyte chemotaxis proteins in patients with Stanford type A aortic dissection
10.3760/cma.j.issn.1001-4497.2016.04.009
- VernacularTitle:Stanford A型主动脉夹层患者血浆单核细胞趋化蛋白的表达及其临床意义
- Author:
Fudong FAN
;
Zhenjun XU
;
Qing ZHOU
;
Dongjin WANG
- Publication Type:Journal Article
- Keywords:
Aortic dissection;
Monocyte chemotaxis proteins;
Hypertension;
C-reactive protein
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2016;32(4):227-229
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the plasma expressions of monocyte chemotaxis proteins(MCPs) in patients with type A aortic dissection and their clinical significance.Methods 51 patients with type A aortic dissection were enrolled,in which 29 combined with hypertension.Fourteen hypertension patients and 1 1 hcalthy subjects were enrolled as control.Plasma samples were collected and we examined the levels of MCP-1,MCP-2 and MCP-4 by enzyme linked immunosorbent assay (ELISA).Results Plasma levels of MCP-1 and MCP-2 significantly decreased in patients with type A aortic dissection compared to healthy subjects(P ＜0.001),while MCP-4 had no change.Type A aortic dissection patients with or without hypertension both showed significant decreased plasma MCP-1 and MCP-2 levels compared to hypertension patients(P ＜0.001).There was no change of MCP-4 among different groups.Furthermore,Spearman correlation analysis showed that there was no correlation between serum CRP levels and plasma MCP-1,MCP-2 concentrations.Conclusion Plasma MCP-1 and MCP-2 may participate in the pathogenesis of type A aortic dissection,and their concentrations were not correlated with hypertension or serum CRP levels.The detailed mechanism needs further observations.
