Angiolymphatic invasion as a prognostic predictor after radical resection of esophageal squamous cell carcinoma

VernacularTitle:脉管癌栓对食管鳞状细胞癌预后的影响
Author: Yushang YANG ; Weipeng HU ; Longqi CHEN
Publication Type:Journal Article
Keywords: Esophageal neoplasms; Carcinoma,squamous cell; Prognosis; Lymphatic vascular invasion
From: Chinese Journal of Thoracic and Cardiovascular Surgery 2015;31(11):656-659
CountryChina
Language:Chinese
Abstract: Objective To investigate the prognostic significance of the angiolymphatic invasion(ALI) in patients with esophageal squamous cancer(ESCC) who received radical resection.Methods A retrospective review was performed on 355 patients who underwent radical resection for ESCC in our hospital between June 2005 and December 2008.Clinicopathological features and overall survival rate were surveyed.Results Of all the patients included, these 46 ESCC patients with angiolymphatic(ALI group) invasion accounted for 13.3％.The 5-year overall survival rate was 20.3％ in patients of ALI group and 40.2％ in those of non-ALI group(P =0.001).The histological differentiation was poorer in the ALI group (P =0.008) as compared with non-ALI group.Univariate analysis showed that body mass index(BMI), ALI, T stage, N stage, and differentiation were associated with survival(P ＜ 0.05 for all).Multivariate analysis revealed that ALI, N stage, T stage and BMI were independent risk factors of prognosis.Conclusion This study highlights that ALI may facilitate the stratification of patients with a poor prognosis after radical resection for ESCC.