Study of the relationships between myeloid-derived suppressor cells (MDSC) and nonresolving inflammation (NRI) in tumor microenvironment
10.3760/cma.j.issn.0254-5101.2016.01.014
- VernacularTitle:肿瘤微环境中的髓源性抑制细胞(MDSC)和非可控性炎症(NRI)相关性研究
- Author:
Jiawei MA
;
Lei HONG
;
Aidong WANG
;
Jun DONG
;
Qiang HUANG
- Publication Type:Journal Article
- Keywords:
Myeloid-derived suppressor cells;
Nonresolving inflammation;
Molecular regulatory network;
Targeted therapy
- From:
Chinese Journal of Microbiology and Immunology
2016;36(1):72-78
- CountryChina
- Language:Chinese
-
Abstract:
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immunosuppressive cells derived from bone marrow stem cells.MDSCs can not only strongly inhibit the anti-tumor immune reactions mediated by T cells,but also directly accelerate angiogenesis,tumor progression and metastasis.Nonresolving inflammation (NRI),a major driving factor in the occurrence and development of tumor,and MDSCs are present in tumor microenvironment and become hot topics in recent years.However,the relationships between MDSCs and NRI,especially in the relevant molecular regulatory networks,have not been fully elucidated.The relationships between MDSCs and NRI,the molecular regulatory networks,the key regulatory points and the strategies for targeted treatment are reviewed in this paper based on the current literatures and the work achieved by our research team.
