Clinical analysis of ABO-incompatible pediatric liver transplantation in 16 patients

VernacularTitle:小儿ABO血型不合肝移植16例的临床分析
Author: Chao SUN ; Wei GAO ; Nan MA ; Chong DONG ; Kai WANG ; Shanni LI ; Zhongyang SHEN
Publication Type:Journal Article
Keywords: Pediatric; Liver transplantation; Living donors; Blood group incompatibility
From: Chinese Journal of Organ Transplantation 2015;36(10):577-581
CountryChina
Language:Chinese
Abstract: Objective To evaluate the safety and clinical effect of ABO-incompatible (ILT) pediatric living donor liver transplantation.Method We analyzed 169 pediatric living donor liver transplantation recipients from Sept.20,2006 to Dec.31,2014.There were 16 ABO-incompatible liver transplantation cases.The median age was 6 months.The blood agglutitin titer was monitored.The titer was controlled lower or equal to 1 ∶ 16.The method to decrease blood agglutitin titer included IVIG and plasma exchange.The patients were treated with Tacrolimus combined with methylprednisolone.Basiliximab for injection was used.The patients were followed-up for 9-26months.The survival rate,acute rejection,vascular and biliary tract complications,and infection were monitored.Result All the patients survived.There was once case of acute rejection,1 case of bile duct dilatation,2 cases of portal vein stenosis,8 cases of EBV viremia,5 cases of CMV viremia,and 6 cases of lung infection.The liver functions of all the 16 recipients were recovered within 3 weeks.Conclusion ABO-incompatible liver grafts can be used safely in pediatric patients.