MRI-detected extramural venous invasion for predicting the response to preoperative chemoradiatiotherapy in locally advanced rectal cancer
10.3760/cma.j.issn.1007-631X.2016.03.005
- VernacularTitle:MRI评估直肠壁外静脉浸润对预测局部进展期直肠癌术前放化疗敏感性的价值
- Author:
Haiting XIE
;
Ming CHEN
;
Xin ZHOU
;
Hao WANG
;
Yunkai ZHANG
;
Huanhong ZENG
;
Wei FU
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
Chemoradiotherapy,adjuvant;
Neoplasm metastasis;
Forecasting
- From:
Chinese Journal of General Surgery
2016;31(3):193-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy of MRI-detected extramural venous invasion (mrEMVI) in predicting tumor responses to preoperative chemoradiatiotherapy (pre-CRT) in patients with locally advanced rectal cancer (LARC).Methods The clinicopathological data,tumor response and mrEMVI information of 47 LARC from February 2013 to December 2014 were retrospectively collected.mrEMVI was given 0-4 score according to the degree,3-4 score were defined as mrEMVI positive;patients with mrEMVI positive were divided into three subgroups according to vascular size (large,middle and small).Association between different mrEMVI subgroup and tumor response was analyzed using Fisher exact test.Result 26 patients were mrEMVI positive.18 and 8 patients scored 3 and 4 for mrEMVI positive,respectively;16,6 and 4 patients were small,middle and larger vessels of mrEMVI positive,respectively.Patients with mrEMVI positive had less TRG 0-1 than mrEMVI negative (P =0.019).Scored 4 and larger vessel of mrEMVI positive had less TRG 0-1 than mrEMVI negative (P =0.038 and 0.017).Conclusions mrEMVI positive score 4 or larger vessel predict poor tumor response to pre-CRT in patients of locally advanced rectal cancer.
