The expression of myosin heavy chain 9 in colorectal adenocarcinoma
10.3760/cma.j.issn.1007-631X.2016.02.017
- VernacularTitle:肌球蛋白重链9在结直肠腺癌中的表达及临床意义
- Author:
Zhongtian JIN
;
Fushun WANG
;
Jiye ZHU
;
Xisheng LENG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Adenocarcinoma;
Myosins;
Prognosis
- From:
Chinese Journal of General Surgery
2016;31(2):141-144
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the expression of myosin heavy chain 9 (MYH9) in colorectal adenocarcinoma tissues and its clinical significance.Methods Immunohistochemistry and tissue-array were used to determine MYH9 expression in human colorectal adenocarcinoma tissues and matched adjacent tissues.A statistical analysis was performed to establish the potential correlation between MYH9 expression and the patients' clinicopathological characteristics,tumor progression,and prognosis.Results MYH9 is up-regulated in colorectal adenocarcinoma tissues compared with matched adjacent tissues (P =0.000),and it was shown that MYH9 expression is significantly correlated with age (P =0.050),clinical stage (P =0.000),lymph node (P=0.010) and distant (P =0.000) metastasis,but not with sex,primary sites,grade,infiltration,clinical stage (all P ＞ 0.05);it was also shown that MYH9 expression had a significant influence on prognosis (x2 =20.437,P =0.000).Multivariate analyses showed that high MYH9 expression is an independent poor prognostic factor for overall survival (P =0.013).Conclusions The up-regulation of MYH9 in colorectal adenocarcinoma closely correlates with age,clinical tumor stage,metastasis and patient's survival.
