Loss of Fhit Expression in Cervical Intraepithelial lesion and Invasive Cervical Carcinoma.
- Author:
Bong Gyu LEE
1
;
Jong Seob LEE
;
Dong Hyeok LEE
;
Mi Jin KIM
;
Young Gi LEE
;
Yoon Kee PARK
;
Doo Jin LEE
;
Sung Ho LEE
Author Information
1. Department of Obstetrics and Gynecology, Yeungnam University Hospital, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Fhit Expression;
Cervical Intraepithelial lesion;
Invasive Cervical Carcinoma
- MeSH:
Cervix Uteri;
Female;
Formaldehyde;
Gynecology;
Humans;
Obstetrics
- From:Korean Journal of Obstetrics and Gynecology
2002;45(2):226-233
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The author evaluated the relationship between the loss of Fhit and prognostic factors of invasive cervical carcinomas. METHODS: The formalin prepared tissue specimens of 64 CINs and 27 invasive cervical carcinomas patients diagnosed and treated at the department of obstetrics and gynecology, Yeungnam university hospital from June 1977 to February 2001 were obtained. And then the tissue specimens were analysed & measured by immunohistochemical methods. RESULTS: The loss of Fhit was significantly reduced in invasive cervical carcinomas compared to CINs. But we found there is no relationships between the loss of Fhit and prognostic factors, stage, tumor marker, lymphatic spread and radiation therapy of invasive cervical carcinomas. CONCLUSIONS: Although the loss of Fhit was not related to the precancerous lesion of cervix, we could confirm that the loss of Fhit was important in the progression of precancerous lesions to invasive cervical carcinomas.
