Signal transduction mechanisms underlying ultraviolet-induced inflammatory responses in keratinocytes
10.3760/cma.j.issn.0412-4030.2016.02.020
- VernacularTitle:紫外线诱导角质形成细胞炎症反应信号传导机制研究进展
- Author:
Li LI
;
Xu CHEN
;
Heng GU
- Publication Type:Journal Article
- Keywords:
Ultraviolet rays;
Keratinocytes;
Inflammation;
Signal transduction;
Protein kinases
- From:
Chinese Journal of Dermatology
2016;49(2):140-143
- CountryChina
- Language:Chinese
-
Abstract:
Ultraviolet (UV) is a kind of important environmental factor that can cause dermatitis,photoaging and skin cancerization.The UV-induced production of inflammatory factors by epidermal keratinocytes has been deemed an important molecular event in occurrence of the above diseases.Various receptors,intracellular signal transduction-related regulatory molecules and nuclear transcription factors are involved in UV-induced inflammatory responses in keratinocytes,which mainly include epidermal growth factor receptor,aryl hydrocarbon receptor,peroxisome proliferatoractivated receptor,protein kinase C family,protein kinase B,mitogen-activated protein kinase family,nuclear factor-κB and transcription factor activator protein-l,etc,and constitute a complex inflammatory signal transduction network.
