Senescence of bone marrow mesenchymal stem cells in patients with systemic lupus erythematosus
10.3760/cma.j.issn.0412-4030.2016.01.024
- VernacularTitle:系统性红斑狼疮患者骨髓间充质干细胞衰老的研究进展
- Author:
Zhiqin WANG
;
Xuebiao PENG
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Mesenchymal stem cells;
Aging;
Hematopoietic stem cells;
Telomere;
Epigenesis,genetic
- From:
Chinese Journal of Dermatology
2016;49(1):68-71
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multi-organ and multisystemic involvement and various clinical manifestations.Bone marrow mesenchymal stem cells (BM-MSCs),a kind of non-hematopoietic stem cells originating from the mesoderm,are key components of hematopoietic microenvironment.Recent studies have indicated that SLE is a disorder of stem cells.Both hematopoietic and mesenchymal stem cells (MSCs) are abnormal in SLE,which mainly manifests as changes of biological characteristics,abnormal cytoskeleton and ultrastructure,shortened telomeres,increased telomerase and SA-β-Gal acitivity,decreased differentiative ability,aberrant immunoregulatory effect,and other features of senescence.The mechanism of MSC aging may be related to up-regulated expressions of aging-related genes p53/p21cip1,p16INK4a/Rb and p27kip1/pTEN,elevated levels of reactive oxygen species (ROS),endoplasmic reticulum stress,epigenetic alterations,etc.
