The correlation between HLA-DR or CD38 expression in CD8+ T cells and CD4+ T cells count in treatment-naive HIV/AIDS patients
10.3760/cma.j.issn.0578-1426.2016.01.009
- VernacularTitle:未经抗病毒治疗的HIV/AIDS患者CD8+ T细胞HLA-DR、 CD38表达水平与CD4+ T细胞计数的相关性研究
- Author:
Jing XIE
;
Zhifeng QIU
;
Yang HAN
;
Yanling LI
;
Xiaojing SONG
;
Taisheng LI
- Publication Type:Journal Article
- Keywords:
HIV;
Acquired immunodeficiency syndrome;
CD4+T cell;
Immune activation
- From:
Chinese Journal of Internal Medicine
2016;55(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between CD4+ T cell count and HLA-DR or CD38 expression on peripheral CD8+ T cells in treatment-naive Chinese HIV/AIDS patients.Methods A total of 471 treatment-naive HIV-infected patients and 53 healthy volunteers were enrolled.HLA-DR or CD38 expression on peripheral CD8+ T cells, CD4+ T cell count, naive CD4+ T cell subsets and CD28 expression on T cells were measured by flow cytometry.Plasma HIV RNA load was quantified by real-time PCR (COBAS TaqMan RT-PCR).Mann-Whitney U test and Spearman's rank correlation test were used for statistical analysis.Results CD38 expression intensity on CD8+ T cells was negatively correlated with CD4+ T cell count (r =-0.53, P ＜ 0.001) and naive CD4+ T cell count (r =-0.48, P ＜ 0.001).CD38 expression on CD8+ T cells also displayed significantly negative correlation with CD28 expression on CD8+ T cells (r =-0.46, P ＜ 0.001).HLA-DR expression on CD8+ T cells did not show significant correlation with CD4+ T cell count.Only weak positive correlation was found between CD38 intensity on CD8+ T cells and plasma HIV RNA load.Conclusions Compared with HLA-DR, CD38 expression on CD8+ T cells shows more significant negative correlation with CD4+ T cell count in treatment-naive patients.CD38 and HLA-DR may play different roles on the persistent immune activation in HIV infection.
