Influence of hyperuricemia to the expression of IRS-1, IRS-2, and GLUT-4 mRNA in fat and skeletal muscle of male rats
10.3760/cma.j.issn.1000-6699.2015.10.016
- VernacularTitle:持续性高尿酸血症致大鼠脂肪和骨骼肌组织IRS-1、IRS-2及GLUT-4 mRNA表达的动态变化
- Author:
Qian WANG
;
Luxia LIANG
;
Shengli YAN
- Publication Type:Journal Article
- Keywords:
Hyperuricemia;
Insulin receptor substrates;
Glucose transporter-4
- From:
Chinese Journal of Endocrinology and Metabolism
2015;31(10):902-905
- CountryChina
- Language:Chinese
-
Abstract:
Basic biochemical index were measured weekly in hyperuricemia rats.Real-time quantitative PCR technology was employed to measure glucose transporter-4 (GLUT-4),insulin receptor substrate (IRS)-1,and IRS-2 mRNA expression in the skeletal muscle and adipose tissue.The gene expression of GLUT-4 and IRS-2 are significantly lower in the last weeks of the hyperuricemia rat.Insulin resistance caused by hyperuricemia is probably related to the lowering expression levels of GLUT-4 and IRS-2 mRNA in the target tissues.
