Expression of IgG4 in thyroid tissues of Hashimoto's thyroiditis and its clinical and histological characteristics

VernacularTitle:桥本甲状腺炎病理组织中IgG4的表达及其临床、组织学特征分析
Author: Shuhan SHI ; Ling LIN ; Chunlin WU ; Qiufang OUYANG
Publication Type:Journal Article
Keywords: Hashimoto's thyroiditis; Immunoglobulin G
From: Chinese Journal of Endocrinology and Metabolism 2015;31(10):883-886
CountryChina
Language:Chinese
Abstract: Immunohistochemistry was carried out for assessment of the expression of IgG4 and IgG in 29 patients with Hashimoto's thyroiditis (HT) and 26 other patients with subacute thyroiditis,thyroid adenoma,and thyroid carcinoma.HT group were divided into IgG4 HT (10/29) and non-IgG4 HT (19/29) groups.Statistical analyses of clinical and histological characteristics were also conducted in both groups.2 cases of subacute thyroiditis were IgG4 positive (2/26).The IgG4 positive plasma cells,IgG positive plasma cells,and ratio of IgG4 +/IgG + plasma cells in IgG4 HT cases were significantly higher than non-IgG4 HT ones(P＜0.05).The serum Fl4 in IgG4 HT cases were lower than non-IgG4 HT ones(P＜0.05).After operation,IgG4 HT had a greater proportion for accepting thyroxin treatment(P＜0.05).IgG4 HT is a new-found disease which has particular histological and immunological features and would have good response for cortical hormone therapy.Serum and tissue examination of IgG4 seems to be helpful to the diagnosis of IgG4 HT.