Effect of hyperthermic intraperitoneal perfusion on blood coagulation in patients undergoing laparoscope-assisted radical surgery for gastric cancer
10.3760/cma.j.issn.0254-1416.2015.11.011
- VernacularTitle:腹腔内热灌注对腹腔镜胃癌根治术患者凝血功能的影响
- Author:
Lu LI
;
Jiaqiang ZHANG
;
Huifeng SI
;
Hui ZHANG
;
Fanmin MENG
- Publication Type:Journal Article
- Keywords:
Chemotherapy,cancer,regional perfusion;
Blood coagulation tests;
Laparoscopy;
Stomach neoplasms
- From:
Chinese Journal of Anesthesiology
2015;35(11):1328-1330
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of hyperthermic intraperitoneal perfusion on blood coagulation in patients undergoing laparoscope-assisted radical surgery for gastric cancer.Methods Forty patients of both sexes, aged 40-60 yr, weighing 50-80 kg, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ , undergoing elective radical surgery for gastric cancer, were equally randomized into control group (group C) and hyperthermic intraperitoneal perfusion group (group HIP).The patients were treated with hyperthermic intraperitoneal perfusion for 1 h after the end of the radical surgery in group R.Before induction of anesthesia (T0) , immediately before hyperthermic intraperitoneal perfusion (T1), and at 1 h of hyperthermic intraperitoneal perfusion (T2) , venous blood samples were collected, blood coagulation was measured using thromboelastography, and the reaction time, coagulation time, α angle and maximal amplitude were recorded.Results Compared with group C, no significant change was found in blood coagulation parameters at T0 and T1 (P＞0.05), the reaction time and coagulation time were significantly increased, and α angle and maximal amplitude were decreased at T2 in group HIP (P＜0.05).Conclusion Hyperthermic intraperitoneal perfusion can improve blood coagulation in the patients undergoing laparoscope-assisted radical surgery for gastric cancer.
