Comparison of butorphanol or midazolam alone and combination of the two drugs in preventing etomidate-induced myoclonus during anesthesia induction
10.3760/cma.j.issn.0254-1416.2015.11.010
- VernacularTitle:布托啡诺、咪达唑仑单独或复合用药预防麻醉诱导时依托咪酯诱发患者肌阵挛效果的比较
- Author:
Jing ZHANG
;
Ling LIU
;
Heping LIU
;
Guoyi LYU
- Publication Type:Journal Article
- Keywords:
Butorphanol;
Midazolam;
Etomidate;
Myoclonus
- From:
Chinese Journal of Anesthesiology
2015;35(11):1325-1327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare butorphanol or midazolam alone and combination of the two drugs in preventing etomidate-induced myoclonus during anesthesia induction.Methods One hundred sixty patients, aged 40-64 yr, with body mass index of 20-25 kg/m2, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ , scheduled for elective operations under general anesthesia, were randomly allocated into 4 groups with 40 patients in each group: control group (group C), butorphanol group (group B) , midazolam group (group M) , and butorphanol combined with midazolam group (group BM).Before induction of anesthesia, butorphanol 15.0 μg/kg, midazolam 50 μg/kg, and butorphanol 7.5 μg/kg combined with midazolam 25 μg/kg were injected intravenously over 30 s in B, M and BM groups, respectively.The equal volume of normal saline was given in group C.And 2 min later, etomidate 0.3 mg/kg was injected intravenously over 1 min.The occurrence of myoclonus was recorded within 2 min after administration of etomidate, and the severity of myoclonus was assessed.Results Compared with group C, the incidence and severity of myoclonus were significantly decreased in B, M and BM groups (P＜0.05).Compared with B and M groups, the incidence and severity of myoclonus were significantly decreased in group BM (P＜0.05).There was no significant difference in the incidence and severity of myoclonus between group B and group M (P ＞ 0.05).Conclusion Butorphanol or midazolam alone produces similar efficacy in preventing etomidate-induced myoclonus during anesthesia induction, and the combination of the two drugs provides better efficacy than either alone in the patients.
