The role of immunity mediated by TLR2 in macrophages against tuberculosis in elderly adults
10.3760/cma.j.issn.0254-9026.2016.03.029
- VernacularTitle:巨噬细胞TLR2介导的老年人抗结核免疫研究进展
- Author:
Hong JIANG
;
Limei WANG
- Publication Type:Journal Article
- Keywords:
Tuberculosis;
Mcrophages;
Toll-like receptors
- From:
Chinese Journal of Geriatrics
2016;35(3):338-341
- CountryChina
- Language:Chinese
-
Abstract:
Objective Macrophages are important innate immune cells,and are also the main target cells of Mycobacterium tuberculosis.Macrophages express many kinds of Toll like receptors.TLR2 is a structural component of macrophages in the identification of Mycobacterium tuberculosis.Activation of TLR2 signaling pathway can activate cell signal transduction,induce specific gene expression and secretion of cytokines.Immune function decline in old people and the function of macrophages was also changed.In this article,The role of immunity mediated by TLR2 in macrophages against tuberculosis in the elderly is reviewed.
