Effects of hypoxia-inducible factor-1α on the expression of heat shock proteins 90, Caspase 3 and Caspase 9 after cerebral ischemia-reperfusion
10.3760/cma.j.issn.0254-9026.2016.03.028
- VernacularTitle:缺氧诱导因子1α对脑缺血再灌注损伤后热休克蛋白90及半胱氨酸天冬氨酸蛋白酶3和9表达的影响
- Author:
Zhirong HUI
;
Tao TAO
;
Jian XU
- Publication Type:Journal Article
- Keywords:
Hypoxia inducible factor 1,α subunit;
Cerebral ischemia;
Reperfusion injury;
Heat-shock proteins Hsp 90
- From:
Chinese Journal of Geriatrics
2016;35(3):334-337
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-1α (HIF-1α)is a transcription factor that acts as a master regulator of gene expression induced by low oxygen conditions.HIF-1α is the most sensitive indicator of hypoxia and can be activated by systemic hypoxia,cerebral hemisphere ischemia and cerebral focal ischemia.HIF-1 expression can be induced by hypoxic-ischemic damage after cerebral infarction and exert its effects on hypoxia-inducible downstream genes,thus protecting hypoxic tissues and cells under hypoxic conditions via regulating the expression of its downstream target genes.This article reviews the expression of HIF-1α and its downstream target genes in acute cerebral ischemia,in order to provide a theoretical basis for gene therapy.
