Hepatitis C virus infection increases the incidence of intrahepatic cholangiocarcinoma: a Meta-analysis

VernacularTitle:丙型肝炎病毒感染与肝内胆管细胞癌发病风险关系的荟萃分析
Author: Shujie PANG ; Zhipeng LIN ; Qingwang YE ; Haibin ZHANG ; Ning YANG ; Guangshun YANG
Publication Type:Journal Article
Keywords: Hepatitis C; Hepatitis C virus; Intrahepatic cholangiocarcinoma; Pathogenesis
From: Chinese Journal of Hepatobiliary Surgery 2016;22(1):33-36
CountryChina
Language:Chinese
Abstract: Objective A meta-analysis was conducted to evaluate the correlation between hepatitis C virus (HCV) infection and the incidence of intrahepatic cholangiocarcinoma (ICC).Methods EMBASE,MEDLINE,Web of Science,CNKI,Weipu and Wanfang databases were retrieved to identify eligible studies which were published between January 2000 and May 2015.Pooled odds ratios (OR) with 95％ confidence interval (95％ CI) were calculated using RevMAN 5.3.Results 14 case-control studies and 2 cohort studies were included in this study.As there was great heterogeneity among these 16 studies (Chi2 =53.18,df =15,I2 =72％,P ＜0.05),the random-effect model was employed.The combined risk estimates of all the studies showed a significant increase in ICC incidence with HCV infection (OR =3.96,95％ CI 2.63-5.95,P ＜ 0.05).The Begg funnel plot showed no evidence of publication bias.Conclusion HCV infection is related to an increased risk of ICC incidence.