Recent progress in the combination treatment of radiotherapy and PD-1/PD-L1 signaling blockade immunotherapy
10.3760/cma.j.issn.0254-5098.2016.03.015
- VernacularTitle:放射治疗联合阻断PD-1/PD-L1通路肿瘤免疫治疗的新进展
- Author:
Shang CAI
;
Ye TIAN
;
Bo XU
- Publication Type:Journal Article
- Keywords:
Radiotherapy;
PD-1/PD-L1 signal blockade;
Oncology immunotherapy
- From:
Chinese Journal of Radiological Medicine and Protection
2016;36(3):235-240
- CountryChina
- Language:Chinese
-
Abstract:
Every stage of tumor initiation and development closely relates to immune regulation as tumor cells tend to evade attacks from immune system by employing the programmed death 1 (PD-1)/ programmed death-ligand 1 (PD-L1) interaction.Therefore,targeting the PD-1/PD-L1 pathway has become an attractive approach for cancer immunotherapy.Radiotherapy has long been considered a local tumor treatment modality and it is immune-inhibitory.However,accumulated evidence has shown that radiotherapy might enhance immune function by eliminating the tumor mass and has become a systemic tumor treatment modality.These observations indicate a strong rationale that the radiotherapy and anti-PD1 and anti-PD-L1 immunotherapy may work synergistically to provide a powerful anti-tumor effect.This review discusses current progresses,challenges and perspectives of this novel combination treatment modality.
