Research progress of oxidative stress in radiation-induced lung injury
10.3760/cma.j.issn.0254-5098.2016.04.017
- VernacularTitle:氧化应激在放射性肺损伤中的相关研究进展
- Author:
Xi CHEN
;
Lujun ZHAO
;
Liming XU
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
Oxidative stress;
Radiation-induced lung injury;
Reactive oxygen species
- From:
Chinese Journal of Radiological Medicine and Protection
2016;36(4):312-315
- CountryChina
- Language:Chinese
-
Abstract:
Although it has been frequently used to treat thoraxic tumors,radiation induced lung injury (RILI) is the major factor of dose limitation in thoracic radiotherapy.Amount of endogenous and exogenous reactive oxygen / nitrogen species (ROS/RNOS) could be generated in the radiated organisms and further cause molecular damage of DNA,protein and membrane lipids,which results in celluar structure damage,dysfunction and RILI.In addition,a series of cytokines could also induce chronic oxidative stresses that contribute to increases in cell membrane permeability,tissue edema and extracellular matrix proteins accumulation and even further result in pulmonary fibrosis.Oxidative stress theory offers new clues and strategies for further understanding the mechanism of RILI,and some anti-oxidative stress drugs may have potential clincial application in RILI treatment.
