Effects of long term exposure of 18F-FDG-PET/CT on rabbit immune system

VernacularTitle:18F-FDG-PET/CT长期照射对兔免疫指标的影响
Author: Wei ZHANG ; Yi LUO ; Jieqing LI ; Yi LIU
Publication Type:Journal Article
Keywords: 18F-FDG-PET/CT; Long-term irradiation; Immune system
From: Chinese Journal of Radiological Medicine and Protection 2016;36(4):264-267
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of long term exposure of 18F-FDG-PET/CT X-rays on rabbit immune system.Methods The rabbits were irradiated with 18F-FDG-PET/CT every day and this irradiation treatment continued for 3 months.At each month,the total number of white blood cells,thymus index and spleen index,phagocytic index,immune globulins,TNF-α and IL-1 in peripheral blood and serum were detected.Results After long-term 18F-FDG-PET/CT irradiation,the total number of white blood cells increased,the thymus and spleen index decreased (t =3.144-72.903,P ＜ 0.05),the phagocytic index and phagocytic percentage decreased after 1 or 2 months(t =2.719-11.859,P ＜ 0.05),and the number of immune cells marked with CD4 + increased but CD8 + decreased(t =6.433-29.877,P ＜ 0.05).In addition,the level of immune globulin in the serum decreased,but the expressions of TNF-α and IL-1β increased (t =2.720-28.775,P ＜ 0.05).Conclusions 18F-FDG-PET/CT has some damage effects on the immune system of male Japanese big ear rabbit,suggesting that the negative effects of PET-CT should be paid close attention to during clinical application.