The expression and significance of serum guanine nucleotide dissociation inhibitor 2 and natural killer cell activation receptor 2D in patients with advanced lung cancer
10.3760/cma.j.issn.1008-6315.2016.01.016
- VernacularTitle:晚期肺癌患者血中鸟嘌呤核苷酸解离抑制因子2和自然杀伤细胞活化受体2D的表达及意义
- Author:
Long YU
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Guanine nucleotide dissociation inhibitory factor 2;
Natural killer cells activated receptor 2 D;
Clinical stage;
Lymph node metastasis
- From:
Clinical Medicine of China
2016;32(1):54-57
- CountryChina
- Language:Chinese
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Abstract:
Objective To study expression clinical significance of serum guanine nucleotide dissociation inhibitor 2 (RhoGDI2), natural killer ccll activation receptor 2D (NKG2D) in patients with advanced lung cancer.Methods From January 2012 to December 2014,50 cases of middle-late stage lung cancer patients as the research object,20 patients with lung adenocarcinoma, 18 cases of adenocarcinoma of lung, 12 cases with small cell lung cancer;30 cases of phase Ⅲ, 20 cases of Ⅳ;22 cases of lymph node metastasis, 28 cases without lymph node metastasis.From January 2012 to December 2014,50 healthy subjects as control group.Flow cytometry instrument was used to detect NKG2D, and ELISA method was used to detect RhoGDI2.Results The RhoGDI2 level of lung cancer patients in Ⅳ, Ⅲ stage higher than the control group ((70.19±8.54), (49.76 ±7.25) vs (5.62± 1.26) μg/L)), the NKG2D level lower than the control group ((71.49± 5.57)％, (78.97 ±6.62)％ vs (84.59±6.96)％ ,P＜0.05).The RhoGDI2 level of lung cancer patients with stage Ⅳ was higher than that of patients with stage Ⅲ((70.19±8.54) μg/L vs (49.76±7.25) μg/L) ,while the NKG2D level of lung cancer patients with stage Ⅳ was lower than that of patients with stage Ⅲ((71.49±5.57) ％ vs (78.97 ±6.62) ％, P＜0.05).RhoGDI2 level of patients with lymph node metastasis was higher than that of patients with no lymph node metastasis((71.32±6.79) μg/L vs (48.29±2.36) μg/L,P＜0.01) ,NKG2D level of lymph node metastasis was lower than without lymph node metastasis in patients ((72.36 ± 6.62)％与 (81.27 ±6.86)％, P ＜0.01).There was negative correlation between serum RhoGDI2, NKG2D expression (r =-4.176, P =0.011).Conclusion There are relationship between the abnormal expression of RhoGDI2 and NKG2D with the clinical stages,lymph node metastasis of the tumor of lung cancer, and has nothing to do with the type of lung cancer.There is negative correlation between the expression of RhoGDI2 and NKG2D.
