Clinical significance of changes of coagulation, fibrinolytic function and platelet parameters before and after chemotherapy in lung cancer patients
10.3760/cma.j.issn.1008-6315.2016.03.021
- VernacularTitle:肺癌患者化疗前后凝血、纤溶功能及血小板参数变化的临床意义
- Author:
Yahui WANG
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Coagulation;
Fibrinolytic function;
Platelet function
- From:
Clinical Medicine of China
2016;32(3):263-266
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the clinical significance of changes of coagulation,fibrinolytic function and platelet parameters before and after chemotherapy in lung cancer patients.Methods Sixty-five cases patients with lung cancer were selected as research object and 65 health persons were selected as the control group.The prothrombin time (PT),thrombin time (TT),activated partial clotting enzyme live time (APTT),fibrinogen (FIB),D-dimer (D-D),the original plasma protein C (PC),fibrinolytic enzyme activator inhibitor-Ⅰ (PAI-Ⅰ),the platelet count (PLT),platelet deposited (PCT),platelet distribution width (PDW) and mean platelet volume(MPV) of the control group,lung cancer patients before and after chemotherapy were tested and compared.Results The levels of PT,TT,APTT,PC,FIB,D-D,PAI-T,PLT,PCT,MPV and PDW of the control group,lung cancer group of before and after chemotherapy were (11.24±0.36) s,(11.56±0.64) sand (10.42±0.64) s,(13.52±1.23) s,(13.56±1.04) sand (12.43±1.26) s,(29.74±2.53) s,(30.05 ± ±2.31) sand (28.53±2.25) s,(4.52±0.52) mg/L,(3.67±0.42) mg/L and (3.25±0.35) mg/L,(3.24±0.53) g/L,(4.26±0.63) g/L and (3.72± 0.25) g/L,(143.53± 34.73) μg/L,(745.63 ± 253.543) μg/L and (435.67±164.73) μg/L,(26.53±7.35) μg/L,(46.63±12.65) μg/L and (85.67±32.63) μg/L,(221.74± ± 53.62) × 109/L,(284.24± 58.25) × 109/L and (204.73 ± 47.1) × 109/L,(0.22 ± 0.06) ％,(0.26 ± 0.12) ％ and (0.21±0.04)％,(10.03±0.64)fl,(10.64±1.052) fl and (9.64±0.84) fl,(15.59±1.53) fl,(16.15±2.53) fland (15.22±2.18) fl respectively.There were no statistically significant difference about PT,TT,APTT and PDW between lung cancer group of before chemotherapy and control group (t =-0.773,-0.142,-0.241 and-0.844;P＞0.05).The PC level of lung cancer group of before chemotherapy was obviously lowerthan that of control group(t=5.354,P＜0.05),and levels of FIB,D-D,PAI-T,PLT,PCT and MPV obviouslyhigher than that of control group(t=-4.246,-7.563,-6.533,-5.243,-4.956 and-5.354;P＜0.05).After chemotherapy,the levels of PT,TI,APTI,FIB,PC,D-D,PLT,PCT and MPV of lung cancer group decreased obviously while the level of PAI-T was obviously increased,the differences were statistically significant (t =4.366,5.104,4.963,5.453,6.452,7.343,5.452,6.043,5.452 and-5.934;P＜0.05).Conclusion The coagulation,fibrinolytic function and platelet of patients with lung cancer and platelet function obvious anomalies and show a high condensation and secondary fibrinolytic state of hyperthyroidism.Chemotherapy can increase the disfunction of coagulation.
