Meta-analysis of the level of adiponectin in chronic obstructive pulmonary disease

VernacularTitle:慢性阻塞性肺疾病患者血清脂联素水平研究的Meta分析
Author: Zhiying LI ; Jian XU ; Jiming CHEN ; Yilu LI ; Li NIE
Publication Type:Journal Article
Keywords: Chronic obstructive pulmonary disease; Adiponectin; Meta-analysis
From: Clinical Medicine of China 2016;32(2):142-145
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical significance of the level of adiponectin (APN) in patients with chronic obstructive pulmonary disease(COPD).Methods The case-control study involving APN in OSAHS were searched and identified from Cochrane Library,PubMed,Embase,China Academic Journals Full-text database,VIP Database,and Full text database of China' s.According to inclusion and exclusion criteria,evaluated the quality of choice experiment,and then extracted the valid data for meta-analysis.Results Seven articles were selected,including 2 in SCI,5 in Chinese.Meta analysis showed that APN in acute exacerbation COPD group was significantly higher than in COPD group (standardized mean difference (SMD) =2.32,95％CI=0.62-4.02,P＜0.05).Compared with normal control group,APN in COPD was higher (SMD=1.39,95％CI=1.00-1.78,P＜0.01).Determined publication bias by Begg's and Egger's test,the results did not show any bias (P＞ 0.05).Conclusion The serum APN of COPD patients are significantly elevated,the APN testing in some extent reflect the severity of COPD.