Investigation of mineral bone disorders in pre-dialysis patients with chronic kidney disease

VernacularTitle:慢性肾脏病非透析患者矿物质骨代谢紊乱的研究
Author: He LI ; Wendi DAI ; Wenhu LIU
Publication Type:Journal Article
Keywords: Kidney diseases/ME; Minerals/ME; Vitamin D/ME
From: Journal of Chinese Physician 2016;18(2):195-198
CountryChina
Language:Chinese
Abstract: Objective To investigate mineral bone metabolic conditions of pre-dialysis patients with chronic kidney disease (CKD),and obtain useful information about the management and treatment of CKD.Methods The levels of serum calcium,phosphate,25-HydroxyvitaminD [25 (OH) VitD],and intact parathyroid hormone (iPTH) were compared.Then a correlation analysis was performed for 25 (OH)VitD.Results Hypocalcemia,hyperphosphatemia,secondary hyperparathyroidism and inadequate of 25 (OH) VitD appeared early in CKD2.Deficiency of 25 (OH)VitD was widespread in CKD2 ～ 5.Multiple linear regression analysis showed that 25 (OH) VitD was independently associated with adjusted level of calcium (P =0.002),application of calcium carbonate (P =0.038),and application of calcitriol (P =0.049) (R square =0.360,P =0.000).Conclusions Mineral bone disorder emerges early in CKD2.More attention should be paid to the management of 25 (OH)VitD.