The research progress of dendritic cell vaccine
10.3760/cma.j.issn.1008-1372.2016.01.047
- VernacularTitle:树突状细胞疫苗的研究进展
- Author:
Yajun LUO
- Publication Type:Journal Article
- Keywords:
Dendritic cells/IM;
Vaccines
- From:
Journal of Chinese Physician
2016;18(1):140-143
- CountryChina
- Language:Chinese
-
Abstract:
The function of dendritic cells had disorder and imbalance,which could cause the defi-ciency of antitumor immune response and the low reactivity of tumor immunotherapy in cancer patients.Dendrite cells (DCs) were further regulated and activated by DC based tumor vaccine and in order to enhance the antitumor immune response that can enhance the ability of scavenging for tumor patients.The dendritic cell-based immunotherapy against tumor has been developed for almost two decades,the DC vaccines can induce specific antitumor immune response and with few side effects in phase Ⅰ / Ⅱ of clinical studies,now some have entered into phase llⅢ of clinical trials.The application of DC vaccines partially benefits the tumor patients,and prolongs the survival of the patients.In this article,the original dendritic cell vaccine basis for a variety of technical improving and changing of strategy to develop the second generation dendritic cell vaccines were reviewed systematically.
