The expression and clinical significance of Chemerin in cervical intraepithelial neoplasia and cervical cancer
10.3760/cma.j.issn.1008-1372.2016.01.023
- VernacularTitle:血清Chemerin水平在宫颈上皮内瘤变及宫颈癌中的表达及临床意义
- Author:
Xuefeng LIU
;
Yansong LI
- Publication Type:Journal Article
- Keywords:
Adipokines/ME;
Cervical intraepithelial neoplasia/ME;
Uterine cervical neoplasms/ME
- From:
Journal of Chinese Physician
2016;18(1):81-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of Chemerin in cervical intraepithelial neoplasia(CIN) and cervical cancer and its relation with clinicopathological characteristics.Methods The expression of Chemerin was determined with enzyme-linked immunosorbent assay (ELISA) in 35 cervical cancer cases,20 cervical intraepithelial neoplasia cases and 20 normal persons.The association of serum level of Chemerin with clinicopathological charactersistics was analyzed.Results The level of Chemerin was the highest in cervical cancer cases [(2113.35 ± 198.64) ng/L],higher in CIN [(1562.78 ± 158.65) ng/L],and low in normal persons [(946.36 ± 113.57) ng/L],showing significant difference among three groups.The serum level of Chemerin in cervical cancer were positively correlated with Federation International of Gynecology and Obstetrics (FIGO) stage and lymph node metastasis (P ＜ 0.05).Serum Chemerin levels were increased with clinical FIGO stage and showed significantly positive correlation with FIGO stage (rs =0.92,P =O.000).Conclusions The expression of Chemerin in patients with cervical carcinoma is increased.Chemerin may be used as reference indicator to predict its progression in cervical carcinoma.
