Clinical study of different doses of oxycodone for severe pain in cancer patients
10.3760/cma.j.issn.1008-1372.2016.01.008
- VernacularTitle:不同剂量羟考酮对重度癌痛患者疼痛抑制的作用研究
- Author:
Wenwen LI
;
Lei HAN
;
Zhiguo ZHANG
;
Li LI
;
Hongwei GUO
;
Pei XUN
;
Jian LUO
- Publication Type:Journal Article
- Keywords:
Oxycodone/AD;
Neoplasms/CO;
Pain/ET/DT
- From:
Journal of Chinese Physician
2016;18(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the optimal dose of oxycodone for severe pain in cancer patients so as to try to alleviate the suffering rapidly.Methods Totally 135 cases with severe pain in terminal cancer patients were randomly divided into groups A,B,and C,45 cases in each group.Groups A,B,and C were treated with oxycodone hydrochloride sustained-release tablets 20 ～ 140 mg/d,150 ～ 290 mg/d,300 ～ 640 mg/d,respectively.Pain relief and incidence of adverse reactions were evaluated 2 weeks later.Results Pain intensity scores (numerical rating scale,NRS) in 3 groups dropped with statistical difference (P ＜ 0.05).Pain relief rates in groups B and C were statistically significant compared to group A (P ＜ 0.05).Quality of life score (appetite,mental status,sleep,daily activities,and interpersonal life) in group C had statistical significance compared to groups A and B (P ＜ 0.05).Group C had slightly higher incidence of adverse reactions than that of groups A and B without significant difference (P ＞ 0.05).Conclusions Large dose and extra large dose of oxycodone hydrochloride sustained-release tablets can effectively relieve severe pain in advanced cancer patients.Extra large dosage can improve patient's quality of life in spite of the higher incidence of adverse reactions,and patients can still be tolerated well.
