Expression of heat shock protein 72 in liver tissues of patients with biliary atresia
10.3760/cma.j.issn.1008-1372.2016.03.016
- VernacularTitle:胆道闭锁儿童肝组织中HSP72的表达意义
- Author:
Zimin CHEN
;
Bin WANG
;
Zhouguang WU
- Publication Type:Journal Article
- Keywords:
Biliary atresia/ME;
Liver/ME;
HSP72 heat-shock proteins/ME
- From:
Journal of Chinese Physician
2016;18(3):384-387
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between heat shock protein 72 (HSP72) and liver fibrosis in pediatric patients with biliary atresia and the significance of its expression.Methods The clinical and pathological data of 30 patients with biliary atresia were selected from June 2013 to June 2015,and the expression of HSP72 in liver tissues was determined by streptomycin peroxide (SP) immunohistochemical method.Results The greater group of liver fibrosis degree with biliary atresia was less than the lighter group in the expression of HSP72 (Z =-4.16,P ＜ 0.01).There was negative correlation between HSP72 expression intensity and operation age (r =-0.704,P ＜ 0.01).Meanwhile,there was negative correlation between HSP72 expression intensity and postoperative cholangitis (r =-0.371,P ＜ 0.05).When the expression of HSP72 was higher,the autologous liver survival rate was higher (x2 =9.482,P ＜ 0.01).Conclusions The expression of HSP72 in liver tissues of patients with biliary atresia is closely related to the degree of liver tissue fibrosis.HSP72 expression may be one of the factors affecting the prognosis of patients with biliary atresia,and can be used as a reference index for evaluating prognosis.
