Efficacy of adefovir dipivoxil combined with interferon α-2b in treatment of chronic hepatitis B patients

VernacularTitle:阿德福韦酯联合国产重组人干扰素α-2b对慢性乙肝患者抗病毒疗效的对比分析
Author: Lin QIAN ; Xiaoxuan HU ; Hongjuan LIU
Publication Type:Journal Article
Keywords: Phosphonic acids/AD; Adenine/AA/AD; Interferon alfa-2b/AA/AD; Hepatitis B,chronic/DT
From: Journal of Chinese Physician 2016;18(3):366-369
CountryChina
Language:Chinese
Abstract: Objective To investigate clinical efficacy of adefovir dipivoxil (ADV) combined with interferon α-2b in treatment of chronic hepatitis B.Methods During Jan 2008 to Dec 2014,ninety patients with chronic hepatitis B were divided into adefovir dipivoxil group (33 cases),interferon group (28 cases),and adefovir dipivoxil combined with interferon α-2b group (29 cases).Alanine aminotransferase (ALT) normalization rate,negative rate of HBV-DNA,and HBeAg/anti-HBe seroconversion rates were evaluated among three groups.Results After 48 weeks of treatment,HBeAg negative rate,HBV-DNA negative rate,and ALT normalization rate of combination group were significantly higher than that of interferons αt-2b group and adefovir dipivoxil group (P ＜ 0.05).Conclusions Adefovir dipivoxil combined with interferon α-2b treatment can inhibit the hepatitis B virus,increase the negative rate of HBV-DNA and HBeAg,and reduce liver cell damage.