Study on the dose-effect relationship of sufentanil with dexmedetomidine after hip arthroplasty in PCIA
10.3760/cma.j.issn.1008-1372.2016.02.020
- VernacularTitle:不同剂量舒芬太尼联合右美托咪啶用于髋关节置换术后静脉镇痛的量效关系
- Author:
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
Sufentanil/AD;
Dexmedetomidine/AD;
Arthroplasty,replacement,hip;
Analgesia
- From:
Journal of Chinese Physician
2016;18(2):236-239
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dose-effect relationship of sufentanil combined with dexmedetomidine which used in clinical effectiveness and safety of intravenous analgesia after hip arthroplasty.Methods Sixty patients (after hip arthroplasty) were randomly divided into three groups:group A (sufentanil 0.5 μg/kg),group B (sufentanil 0.75 μg/kg),and group C (sufentanil 1 μg/kg).Each group was combined with dexmedetomidine 1.5 μg/kg in patient controlled analgesia (PCA) pump.Mean arterial pressure (MAP),heart rate (HR),SpO2,numerical rating scale (NRS) scores,and Ramsay sedation scores were recorded at T1 (4 h after operation),T2 (8 h after operation),T3 (24 h after operation),and T4(48 h after operation).Harris hip scores were recorded at T0(preoperative),T3,and T4.The total number of pushing patient controlled intravenous analgesia (PCIA),dezocine dosage,and the occurrence of adverse events in each group situation were recorded.Results There were no significant differences in MAP,HR,and SpO2 among groups.Compared to group A,NRS scores of groups B and C were lower during the analgesia (P ＜0.01).Compared to group A,Ramsay sedation scores of groups B and C were higher at T1,and T2 (P ＜ 0.01).Compared to group A,Harris hip scores of groups B and C were higher at T3,and T4 (P ＜ 0.01).Compared to group C,adverse reactions of groups A and B were less during the analgesia (P ＜ 0.01).Compared to group A,the total number of press PCIA and dezocine amount were decreased in groups B and C (P ＜ 0.01).Conclusions The 0.75 μg/kg sufentanil combined with 1.5 μg/kg right beauty holds the minimum for intravenous analgesia effect after hip arthroplasty and calm exactly satisfied,less adverse reaction,for PCIA ideal drug formula.
