Research progress in TWEAK and its receptor functions in cardiovascular diseases
10.7644/j.issn.1674-9960.2016.02.020
- VernacularTitle:TWEAK及其受体在心血管疾病中的作用研究进展
- Author:
Changjiang HONG
;
Quanliang LI
;
Yuan ZHANG
- Publication Type:Journal Article
- Keywords:
TWEAK;
myocardial infarction;
heart failure;
cardiomyopathy;
atherosclerosis;
peripheral vascular disease;
myocardial fibrosis
- From:
Military Medical Sciences
2016;40(2):158-161
- CountryChina
- Language:Chinese
-
Abstract:
Tumor necrosis factor-like weak inducer of apoptosis ( TWEAK ) is a member of the superfamily .TWEAK binds to its receptor [ fibroblast growth factor-inducible 14 ( Fnl4 ) and the serum level of soluble CD 163 ( sCD163 ) ] and regulates many cellular activities via associated signal pathways ,including proliferation,migration,differentiation,apoptosis, angiogenesis and inflammation ,which play a significant role in the formation and development of cardiovascular diseases , such as atherosclerosis , heart failure , cardiomyopathy , and peripheral vascular disease .This review summarizes functions of TWEAK and its receptor in cardiovascular diseases .
