Silica Granuloma after Intermittent Intramuscular Injections: A Case Report.
- Author:
Suk Jin CHOI
1
;
Jong Im LEE
;
Jung Ran KIM
;
Tae Jung JANG
;
Ki Kwon KIM
;
Phil Hyun CHUNG
Author Information
1. Department of Pathology, Dongguk University, College of Medicine, Kyongju, Korea. pathjrk@dumc.or.kr
- Publication Type:Case Report
- Keywords:
Silicon dioxide;
Granuloma;
Injection, Intramuscular
- MeSH:
Aged;
Buttocks;
Collagen;
Dermatitis;
Electron Probe Microanalysis;
Granuloma*;
Humans;
Hyalin;
Inflammation;
Injections, Intramuscular*;
Microscopy, Electron, Scanning;
Sarcoidosis;
Silicon Dioxide*;
Skin;
Wounds and Injuries
- From:Korean Journal of Pathology
2003;37(5):369-372
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Most silica-contaminated wounds of the skin heal without complications. Cutaneous silica granuloma is a poorly understood, uncommon condition resembling a sarcoidosis. We report a case of silica granuloma after intermittent intramuscular injections. A 70-year-old man presented a painless mass in his right buttock for 2 weeks. He had received intermittent intramuscular injections of antihistamine drugs due to chronic dermatitis for 30 years. The histolopathological findings showed numerous hyalinized collagenous nodules with concentric layers, and an ill-defined chronic granulomatous inflammation containing foreign material. A polarized light microscopic examination revealed birefrigent particles. The presence of silica components was confirmed by scanning electron microscopy and energy dispersive X-ray microanalysis.
