Expression of p53 Protein and Ki-67 Antigen in Porokeratosis.
- Author:
Sung Jun KIM
1
;
Chang Keun OH
;
Moon Bum KIM
;
Ho Sun JANG
;
Kyung Sool KWON
Author Information
1. Department of Dermatology, College of Medicine, Pusan National University Pusan, Korea. ckoh@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Porokeratosis;
p53 protein;
Ki-67 antigen
- MeSH:
Antibodies;
Epidermis;
Ki-67 Antigen*;
Paraffin;
Porokeratosis*
- From:Korean Journal of Dermatology
2001;39(11):1267-1274
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Porokeratosis is a rare group of disorders of epidermal keratinization which is histologically characterized by the presence of cornoid lamella. The malignant potential of porokeratotic lesions is well recognized. Recently, frequent p53 overexpression has been reported and might be related to the carcinogenic potential of porokeratosis. OBJECTIVE: To compare previous foreign results of p53 overexpression in porokeratosis with Korean cases, we studied 24 Korean cases of porokeratosis(7 of Porokeratosis of Mibelli, 14 of DSAP, 2 of Linear Porokeratosis, and 1 of PPPD). METHODS: Immunohistochemical staining was done on the paraffin sections using a labelled streptavidin-biotin-peroxidase complex method with primary antibodies against p53 protein and Ki-67. RESULTS: The epidermis central to cornoid lamellae was positive for p53 protein in 15 of the 24 cases. The epidermis beneath the cornoid lamellae was positive in 3 of the central positive 15 cases and the peripheral epidermis was positive in 1 of the central positive 15 cases. Staining for Ki-67 antigen was increased above background levels in 9 of 24 specimens. No correlation was detected between p53 protein expression and Ki-67 antigen expression. CONCLUSION: The p53 overexpression was observed in Korean cases of porokeratosis but, the expression rate of p53 in Korean cases of porokeratosis was relative less than previous foreign reports.
