Association analysis between TNIP1 gene polymorphisms and systemic lupus erythematosus in a Chinese Han population
10.3760/cma.j.issn.0412-4030.2016.03.003
- VernacularTitle:TNIP1基因多态性与汉族人系统性红斑狼疮相关性研究
- Author:
Yong WANG
;
Jianwen HAN
;
Hongbin LI
;
Chulu ALATENG
;
Zhiqiang SUN
;
Xinxiang LYU
;
Rina WU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
Polymorphism,single nucleotide;
Genetic association studies;
Genes,TNIP1
- From:
Chinese Journal of Dermatology
2016;(3):163-167
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate association between polymorphisms of the tumor necrosis factor α-induced protein 3 (TNFAIP3)interacting protein 1 (TNIP1)gene and systemic lupus erythematosus (SLE)in a Chinese Han population. Methods Blood samples were collected from 284 patients with SLE of Han nationality(SLE group)and 630 healthy controls of Han nationality (control group). Ligase detection reaction (LDR)was performed to determine the genotypes of 120 single nucleotide polymorphisms (SNPs)in the TNIP1 gene. Data were analyzed with the PLINK 1.07 package and Haploview software. Results After quality control, data on 105 SNPs underwent statistical analysis finally. Four SNPs including rs3805433, rs12516176, rs6869605 and rs4958882 in the TNIP1 gene were significantly associated with SLE (OR: 1.50 - 1.53, all P < 4.72 × 104), and there was a significant increase in the frequency of rs3805433 C, rs12516176 C, rs6869605 C and rs4958882 G alleles in the SLE group (0.301 - 0.306)compared with the control group (0.221 - 0.225). There was strong linkage disequilibrium between these 4 SNPs (r2 ≥ 0.871, D′ ≥ 0.938). In addition, moderate linkage disequilibrium was observed between these 4 SNPs and a previously reported SLE-related SNP rs10036748 (r2 ≥ 0.073, D′ ≥ 0.868). The frequency of the haplotype H2: CCCGT was significantly higher in the SLE group than in the control group(0.290 vs. 0.210, OR = 1.54, P < 4.72 × 10-4). Conclusion TNIP1 gene polymorphisms are associated with SLE in Chinese Han population.
