Recent advance in diagnosis and treatment of pediatric acute myeloid leukemia
10.3760/cma.j.issn.2095-428X.2016.03.002
- VernacularTitle:儿童急性髓细胞白血病诊断治疗进展
- Author:
Shuhong SHEN
- Publication Type:Journal Article
- Keywords:
Child;
Acute myeloid leukemia;
Chemotherapy;
Targeted therapy
- From:
Chinese Journal of Applied Clinical Pediatrics
2016;(3):165-171
- CountryChina
- Language:Chinese
-
Abstract:
Pediatric acute myeloid leukemia(AML)is still a fatal disease.Recent evidence based clinical study indicated intensified chemotherapy contribute to improvement of pediatric AML survival,while supporting care was an important measurement to let patients tolerate more and more intensifying chemotherapy.Recent series of clinical trial reveals that benefit from more intensified chemotherapy will be limited.Combined risk stratification of genetics and minimal residual desease monitoring may further increase the survival.Tyrosine kinase inhibitors,Gemtuzumab ozogami-cin and Chimeric antigen receptors modified T cell based targeted therapy could be the only way to cure resistant AML. In this review,advance in conventional chemotherapy,hematopoietic stem cell transplantation,and targeted therapy for pediatric AML were reviewed.
