Effects of Low Dose Ultrashort Wave Therapy on Inflammation and Edema after Spinal Cord Injury in Rats
10.3969/j.issn.1006-9771.2016.02.006
- VernacularTitle:小剂量超短波治疗对大鼠脊髓损伤后炎症反应及水肿的影响
- Author:
Yucen WAN
;
Shi SUN
;
Lina ZHAO
;
Yanmei YIN
;
Zhiping FENG
;
Yuxin ZHOU
;
Zhiqiang ZHANG
;
Lixin ZHANG
- Publication Type:Journal Article
- Keywords:
spinal cord injury;
ultrashort wave;
aquaporin-4;
macrophage/microglias;
rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2016;22(2):150-155
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ultrashort wave therapy on edema and inflammatory reaction after spinal cord injury (SCI) in rats. Methods 56 Sprague-Dawley rats were divided into sham-operated group (n=8), model group (n=24) and ultrashort wave group (n=24). The model was established with Allen's method. The sham-operated group was exposed endorhachis without hit. The ultra-short wave group was exposed to ultrashort wave radiation 7 minutes, once a day, 24 hours after modeling until the animals were sacrificed. Locomotors functional recovery was assessed every week post operation period by BBB score. Immunohistochemical staining was per-formed to observe the expression of the aquaporin-4(AQP-4) and ED-1. Results The BBB scores increased in the model group and the ultra-short wave group after treatment, and was higher in the ultrashort wave group than in the model group from 1 week after treatment (t>3.368, P<0.01). The expressions of AQP-4 and ED-1 were higher in the model group and ultrashort wave group than in the sham-operated group, and decreased as time went on. They were lower in the ultrashort wave group than in the model group(t>3.156, t>4.466, P<0.05). Conclu-sion Ultrashort wave therapy can alleviate the edema after SCI, reduce the activation and infiltration of inflammatory cells, and promote the recovery of neurological function.
